Crk proteins transduce FGF signaling to promote lens fiber cell elongation 1 2

نویسندگان

  • Tamica N. Collins
  • Yingyu Mao
  • Hongge Li
  • Michael Bouaziz
  • Angela Hong
  • Sheng Feng
  • Fen Wang
  • Lawrence A Quilliam
  • Lin Chen
  • Taeju Park
  • Tom Curran
چکیده

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Crk proteins transduce FGF signaling to promote lens fiber cell elongation

Specific cell shapes are fundamental to the organization and function of multicellular organisms. Fibroblast Growth Factor (FGF) signaling induces the elongation of lens fiber cells during vertebrate lens development. Nonetheless, exactly how this extracellular FGF signal is transmitted to the cytoskeletal network has previously not been determined. Here, we show that the Crk family of adaptor ...

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Bone morphogenetic protein signaling and the initiation of lens fiber cell differentiation.

Previous studies showed that the retina produces factors that promote the differentiation of lens fiber cells, and identified members of the fibroblast growth factor (FGF) and insulin-like growth factor (IGF) families as potential fiber cell differentiation factors. A possible role for the bone morphogenetic proteins (BMPs) is suggested by the presence of BMP receptors in chicken embryo lenses....

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Evaluation of fibroblast growth factor signaling during lens fiber cell differentiation.

PURPOSE Previous studies have implicated members of the fibroblast growth factor (FGF) and insulin-like growth factor (IGF) families as stimulators of lens fiber cell differentiation in rodent and chicken embryo lenses, respectively. In the present study, the role of FGFs in fiber cell differentiation and epithelial cell proliferation in chicken embryos was examined. METHODS Lenses were injec...

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Wnt signaling enhances FGF2-triggered lens fiber cell differentiation.

Wnt signaling is implicated in many developmental processes, including cell fate changes. Several members of the Wnt family, as well as other molecules involved in Wnt signaling, including Frizzled receptors, LDL-related protein co-receptors, members of the Dishevelled and Dickkopf families, are known to be expressed in the lens during embryonic or postembryonic development. However, the functi...

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Fibroblast growth factor (Fgf) signaling governs multiple processes important in development and disease. Many lines of evidence have implicated Erk1/2 signaling induced through Frs2 as the predominant effector pathway downstream from Fgf receptors (Fgfrs), but these receptors can also signal through other mechanisms. To explore the functional significance of the full range of signaling downstr...

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تاریخ انتشار 2018